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Effects of HNGF6A on GSIS in vivo. A–D) GIR (A, time course; B, average) and insulin levels (C, time course; D, average) in hyperglycemic clamp in young Sprague-Dawley rats (n=18). E–I) Time course (E) and AUC (F) of the effects of HNGF6A on first-phase insulin secretion; C-peptide levels (G); glucose levels (H); and first-phase insulin response (I) in C57BL6/N mice during the IVGTT. Data are presented as means ± sem. *P < 0.05, **P < 0.01.
