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. 2013 Dec;27(12):5010–5021. doi: 10.1096/fj.13-236380

Figure 1.

Figure 1.

Essential roles of both C5aR and C5L2 during the 3 models of ALI. A) Comparison of alveolar permeability after LPS-ALI in C57BL/6J (Wt), C5aR−/−, or C5L2−/− mice. Sham-treated mice received PBS i.t., ELISA for BALF mouse albumin. B) Alveolar permeability after IgGIC-ALI in C57BL/6J (Wt), C5aR−/−, or C5L2−/− mice (ELISA). C) Alveolar permeability after C5a-ALI in C57BL/6J (Wt), C5aR−/−, or C5L2−/− mice (ELISA). D) Cytospins of BALF cells after C5a-ALI in C57BL/6J (Wt), C5aR−/−, or C5L2−/− mice, Wright-Giemsa stains. E) PMN counts in BALF after C5a-ALI in C57BL/6J (Wt), C5aR−/−, or C5L2−/− mice. F) Histopathology after C5a-ALI in C57BL/6J (Wt), C5aR−/−, or C5L2−/− mice (H&E stains). Duration of all ALIs shown was 8 h, and 500 ng i.t. rmC5a was used for C5a-ALI. Data from each experiment shown are representative of n ≥ 7 mice/group. Error bars = sem. *P < 0.05, **P < 0.01, ***P < 0.001; Student's t test.