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. 2013 Dec;27(12):5010–5021. doi: 10.1096/fj.13-236380

Figure 3.

Figure 3.

Protective effects of neutralization of extracellular histones during ALI. A) Reduced alveolar permeability disturbances after C5a-ALI with treatment of neutralizing anti-H4 antibody (BWA3, 250 μg i.v. + 50 μg i.t.) or isotype control IgG1κ, 8 h; ELISA. B) Multiplex bead-based assay of mediators in BALF after C5a-ALI with treatment of anti-H4 antibody or control IgG1κ, 8 h; ELISA. Only mediators with significant differences (P<0.05, 11 of 23 mediators) between groups are shown. C5a was used as 500 ng/mouse i.t. Data were acquired using n ≥ 15 mice/group. Error bars = sem. *P < 0.05; Student's t test.