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. 2013 Dec;27(12):5010–5021. doi: 10.1096/fj.13-236380

Figure 8.

Figure 8.

Extracellular histones mediate lung consolidation and acute histopathology in lungs. A) High-resolution MRI of lungs from C57BL/6J mice after PBS i.t. (sham treatment) or purified histones (20 μg/g body weight), 6 h. Arrowheads indicate signal-intense intrapulmonary areas consistent with consolidation of lung tissue; axial proton density/T1-weighted images; slice thickness: 1 mm. B) High-resolution MRI of lungs from Sprague-Dawley rats 6 h after PBS i.t. (sham) or purified histones (20 μg/g body weight). Arrowheads indicate signal-intense intrapulmonary areas of lung infiltrations; slice thickness: 2 mm. C) Histopathology of lungs from C57BL/6J mice after treatment with purified histones (20 μg/g body weight i.t.) compared to sham-treated lungs, 6 h, H&E staining. D) Transmission electron microscopy of normal lungs (sham treatment) from C57BL/6J mice compared to lungs after exposure to purified histones (100 μg i.t.), 8 h; ×2000. Arrow indicates blebbing of type II pneumocyte; arrowheads indicate fibrin deposits. Data are representative of n ≥ 5 animals/group.