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. 2013 Aug 20;41(21):9753–9763. doi: 10.1093/nar/gkt666

Figure 4.

Figure 4.

miR-146a-5p regulates MSC migration and proliferation. (A and B) miR-146a-5p suppresses MSC motility. WJ-MSCs transfected with siRNAs against GFP or miR-146a-5p (siControl or si146a; A), and BM-MSCs transduced with lentiviruses expressing miR-146a-5p or empty lentivirus vector control (B) were used in Transwell assays. miR-146a-5p levels were detected by RT-qPCR (left panels). Results are shown as mean ± SD from four experiments. *P < 0.05 by t-test. (C) miR-146a-5p controls the proliferation of WJ-MSCs. WJ-MSCs were transduced with lentiviruses encoding a short hairpin against miR-146a-5p (sh146a), and cell proliferation rate was measured at the indicated time points using MTT assays. Results are presented as mean ± SD in two duplicates. *P < 0.05 by t-test.