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. 2013 Aug 19;41(21):9634–9650. doi: 10.1093/nar/gkt725

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Precise sequence of the PS DNA gap region is important for optimal allele selectivity. Dose-dependent reduction of muHTT and wtHTT mRNA in human GM04022 fibroblasts for (A) ASOs A29 (8-base PS DNA gap) and A30 (seven-base PS DNA gap) (b) ASOs A31, A32 and A33 (seven-base PS DNA gaps frame-shifted by one nucleotide). Summary of sequence, activity and selectivity for (C) ASOs A1, A29, A30 and (D) A31, A32 and A33. Underlined nucleotide indicates position across from the SNP site. Error bars are in ±SD.