Skip to main content
. 2013 Aug 26;41(21):9779–9785. doi: 10.1093/nar/gkt754

Figure 1.

Figure 1.

The specificity of the TALE NTD. (A) Illustration of a TALE bound to its target DNA (green, RVD domain; magenta, N-1 hairpin domain). (B) Structural analysis suggests contact of the 5′ T by W232 of the N-1 hairpin. This hairpin shares significant sequence homology with RVD hairpins. (C–F) Analyses of NT-T (wt) NTD in the context of (C) AvrXa7 TALE-R, (D) AvrXa7 TALE-TF, (E) AvrXa7 MBP-TALE and (F) a CCR5 targeting TALEN. (* = P < 0.05, ** = P < 0.01, *** = P < 0.001 compared with 5′ T).