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. 2013 Oct 15;6(6):1723–1728. doi: 10.3892/ol.2013.1630

Figure 4.

Figure 4

PKG II prevents EGF-induced phosphorylation/activation of mTOR. The AGS cells were treated as in Fig. 1 and western blotting with an anti p-mTOR (Ser2448) antibody was performed to analyze the effect of EGF and PKG II on the phosphorylation/activation of mTOR. The results revealed that in the EGF-treated cells, the phosphorylation level of mTOR (Ser2448) increased. Infection with Ad-PKG II+cGMP efficiently inhibited the EGF-induced phosphorylation of mTOR (Ser2448). PKG II, cGMP-dependent protein kinase Type II; EGF, epidermal growth factor.