Figure 1.

Induction of HSP70 expression by HSP90 inhibition in neuroendocrine tumor cells. BON1, NCI-H727 and GOT1 cells were treated with increasing concentrations (1–100 nM) of the HSP90 inhibitors (A) AUY922 and (B) HSP990 for 2 and 24 h. Subsequently the expression of HSP90 and HSP70 was evaluated by western blot analysis. A representative blot of 3 independently performed experiments is shown.