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Effect of HSP90 inhibition on cell cycle distribution of neuroendocrine tumor cells. Human pancreatic neuroendocrine BON1 cells cultured in complete medium were treated with the indicated concentrations (1–100 nM) of the HSP90 inhibitors AUY922 (left panel) or HSP990 (right panel) for 24 h. Demonstrated are the mean values ± SD of 3 independently performed experiments in duplicates (n=6); p<0.001 versus untreated control.
