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Effect of HSP90 inhibition on RTK expression in neuroendocrine BON1 tumor cells. BON1, NCI-H727 and GOT1 cells were treated with increasing concentrations (1–100 nM) of the HSP90 inhibitor AUY922 (left panel) or HSP990 (right panel) for 24 h. Subsequently the expression of EGFR, ErbB2, ErbB3 and IGFIR was evaluated by western blot analysis. A representative blot out of 3 independently performed experiments is shown.
