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. 2013 Oct 4;43(6):1824–1832. doi: 10.3892/ijo.2013.2130

Figure 6.

Figure 6.

Effect of HSP90 inhibition on downstream signaling. BON1, NCI-H727 and GOT1 cells were treated with increasing concentrations (1–100 nM) of the HSP90 inhibitor AUY922 (left panel) or HSP990 (right panel) for 24 h. Subsequently, the expression of pErk1/2, Erk1/2, pAkt, Akt, pp70S6K, p70S6K, p4EBP1 and 4EBP1 was evaluated by western blot analysis. A representative blot out of 3 independently performed experiments is shown.