Table 6.
Sensitivity analysis based on the daily doses of metformin
|
Daily doses |
Outcome |
No. of studies | Pooled sample size |
Heterogeneity |
Overall effect |
|||
|---|---|---|---|---|---|---|---|---|
| T 2 | I 2 | P-value | SMD [95% CI] | P-value | ||||
| Below 1000 mg only |
BMI |
4 |
352 |
0.01 |
22% |
0.28 |
0.33 [0.09, 0.58] |
0.007 |
| |
SBP |
2 |
177 |
0.00 |
0% |
0.64 |
-0.02 [-0.31, 0.28] |
0.92 |
| |
DBP |
2 |
177 |
0.00 |
0% |
0.67 |
-0.06 [-0.36, 0.23] |
0.69 |
| |
FPG |
5 |
584 |
0.02 |
34% |
0.19 |
0.03 [-0.18, 0.24] |
0.77 |
| |
HbA1c |
5 |
584 |
0.07 |
65% |
0.02 |
0.14 [-0.15, 0.44] |
0.34 |
| |
PPBS |
3 |
276 |
0.04 |
46% |
0.16 |
0.02 [-0.32, 0.36] |
0.91 |
| |
TC |
3 |
251 |
0.04 |
41% |
0.18 |
0.32 [-0.03, 0.66] |
0.07 |
| |
HDL |
3 |
251 |
0.00 |
0% |
0.83 |
0.01 [-0.23, 0.26] |
0.91 |
| |
LDL |
1 |
136 |
NA |
NA |
NA |
0.19 [-0.15, 0.53] |
0.27 |
| |
TG |
3 |
251 |
0.00 |
0% |
0.67 |
0.10 [-0.15, 0.34] |
0.44 |
| |
FINS |
4 |
352 |
0.00 |
4% |
0.37 |
0.22 [0.00, 0.43] |
0.05 |
| 1000 mg and above 1000 mg |
BMI |
6 |
636 |
0.87 |
95% |
<0.00001 |
-0.36 [-1.13, 0.41] |
0.36 |
| |
SBP |
3 |
438 |
0.17 |
85% |
0.002 |
0.64 [0.12, 1.16] |
0.02 |
| |
DBP |
3 |
438 |
0.19 |
86% |
0.0009 |
0.60 [0.06, 1.14] |
0.03 |
| |
FPG |
9 |
1027 |
0.04 |
55% |
0.02 |
-0.05 [-0.24, 0.14] |
0.64 |
| |
HbA1c |
8 |
959 |
0.00 |
0% |
0.87 |
-0.08 [-0.21, 0.04] |
0.20 |
| |
PPBS |
8 |
823 |
0.22 |
84% |
<0.00001 |
-0.37 [-0.73, -0.01] |
0.04 |
| |
TC |
6 |
636 |
0.24 |
85% |
<0.00001 |
0.34 [-0.09, 0.77] |
0.12 |
| |
HDL |
6 |
636 |
0.39 |
90% |
<0.00001 |
0.14 [-0.39, 0.68] |
0.59 |
| |
LDL |
5 |
566 |
0.02 |
32% |
0.21 |
0.38 [0.17, 0.59] |
0.0004 |
| |
TG |
6 |
636 |
.0.08 |
67% |
0.010 |
0.36 [0.07, 0.64] |
0.02 |
| |
FINS |
6 |
667 |
0.71 |
95% |
<0.00001 |
-0.02 [-0.72, 0.67] |
0.94 |
| Above 1000 mg only |
BMI |
2 |
234 |
0.11 |
72% |
0.06 |
0.16 [-0.38, 0.69] |
0.56 |
| |
SBP |
2 |
234 |
0.42 |
91% |
0.001 |
0.69 [-0.25, 1.63] |
0.15 |
| |
DBP |
2 |
234 |
0.47 |
92% |
0.0005 |
0.63 [-0.36, 1.63] |
0.21 |
| |
FPG |
3 |
461 |
0.07 |
73% |
0.02 |
0.02 [-0.35, 0.38] |
0.93 |
| |
HbA1c |
3 |
461 |
0.00 |
0% |
0.91 |
-0.16 [-0.34, 0.03] |
0.10 |
| |
PPBS |
3 |
461 |
0.00 |
0% |
0.82 |
-0.11 [-0.29, 0.07] |
0.24 |
| |
TC |
2 |
234 |
0.01 |
17% |
0.27 |
0.23 [-0.07, 0.52] |
0.13 |
| |
HDL |
2 |
234 |
0.00 |
0% |
0.48 |
0.06 [-0.20, 0.32] |
0.64 |
| |
LDL |
1 |
164 |
NA |
NA |
NA |
0.43 [0.12, 0.74] |
0.006 |
| |
TG |
2 |
234 |
0.04 |
49% |
0.16 |
0.16 [-0.23, 0.55] |
0.42 |
| FINS | 4 | 531 | 0.71 | 95% | <0.00001 | 0.28 [-0.57, 1.13] | 0.52 | |
Note: "NA" stands for "not applicable".