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. 2012 Jan 17;4(1):71–92. doi: 10.3390/pharmaceutics4010071

Figure 6.

Figure 6

Relationship between Emax (the maximum enhancement effects) and the product of Koctanol/PBS (octanol/PBS partition coefficient) and Sw (aqueous solubility of enhancer) of the penetration enhancers (closed circles: enhancers, liquid at 37 °C; open circles: enhancers, solid at 37 °C). The average lipid concentration of enhancers to induce E = 10 in the symmetric studies, in which the enhancers were not at saturation, is also presented for comparison (open square). The data are taken from previous human epidermal membrane (HEM) studies [40,41].