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. 2012 Feb 16;4(1):179–196. doi: 10.3390/pharmaceutics4010179

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© 2012 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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pH solubility profile of TMP and TMP-glutamate salt at ambient conditions using free acid (circles) and TMP-glutamate salt (squares) as starting materials. Points b and a represent the saturation solubility of the salt and TMP free base respectively. [Bs] = 266.35µg/mL and pKa = 7.3.