Table 4.
The tmax and t50% of the lymphatic drainage to the popliteal, iliac, and axillary lymph node packages of different MW HA-IR820 conjugates after s.c. administration.
| tmax, h | t50%, h | |||||
|---|---|---|---|---|---|---|
| Sample | Popliteal | Iliac | Axillary | Popliteal | Iliac | Axillary |
| 6.4 kDa HA-IR820 | 1.5 | 4 | 1 | 7.6 ± 3.2 | 16 ± 7 | 10 ± 3 |
| 35 kDa HA-IR820 | 1.5 | 2 | 1–2 | 5.7 ± 1.4 | 4.6 ± 3.6 | 17 ± 6 |
| 74 kDa HA-IR820 | 1.5–2 | 1.5–2 | 3 | 6.9 ± 2.4 | 21 ± 1 | 15 ± 5 |
| 132 kDa HA-IR820 | 1.5 | 2–4 | 4 | 49 ± 15 | 30 ± 6 | 62 ± 22 |
| 357 kDa HA-IR820 | 3 | 3 | 3–4 | 38 ± 11 | 21 ± 9 | 62 ± 26 |
| 697 kDa HA-IR820 | 3 | 2–3 | 3 | 47 ± 9 | 62 ± 19 | 72 ± 8 |