Table 2.

Examples of pharmacokinetic nanoparticle in vitro and in vivo studies.

Author	Study Approach	Reference
Shokeen et al.	Radiolabeled nanoparticles with positron emitting radionuclides along in vitro and in vivo protocols.	[71]
Almeida et al.	Comprehensive review of in vivo biodistribution of nanoparticles, including structure, toxicity and in vitro comparison.	[72]
Khlebtsov et al.	Comprehensive review of in vitro and in vivo biodistribution of nanoparticles, with nanoparticle parameters, used doses and toxicity.	[73]
Pires et al.	Treatment of breast cancer using paclitaxel associated to an artificial lipid nanoemulsion, emphasizing the improved pharmacokinetic parameters and the reduced toxicity of the drug.	[74]
Maranhão et al.	Plasma kinetics and biodistribution of an artificial lipid nanoemulsion in patients with acute leukemia.	[43]
Azevedo et al.	Plasma kinetics and biodistribution of an artificial lipid nanoemulsion associated to etoposide oleate in patients with ovarian carcinoma.	[44]
Saha et al.	Review of preparation, characterization, biodistribution and pharmacokinetic of nanosystems for cancer chemotherapy.	[75]