Table 2.
Vascular disrupting agents.
| Compounds | Dose/schedule | DCE-MRI | References |
|---|---|---|---|
| Tubulin binding | |||
| CA4P | 1-2 × 10-250 mg/kg (mouse) | 1-24 h | [77,111,112,113,114,115,116,117,118,119,120,121] |
| 1 × 10-100 mg/kg (rat) | 1 h-9 days | [70,122,123,124,125] | |
| OXi4503 | 1-2 × 25-100 mg/kg (mouse) | 4-144 h | [114] |
| ZD6126 | 1 × 50-200 mg/kg (mouse) | 24 h | [126,127] |
| 1 × 2.5-50 mg/kg (rat) | 1-120 h | [125,128,129,130,131] | |
| NPI2358 | 1 × 2.5-15 mg/kg (mouse) | 1-24 h | [132] |
| Stilbene 5c and 6c | 1 × 50 mg/kg (mouse) | 4 h | [133] |
| TZT-1027 | 1 × 0.5 mg/kg (rat) | 1-3 h | [134] |
| ABT-751 | 1 × 30 mg/kg (rat) | 1-6 h | [135] |
| TNF-α inducing | |||
| DMXAA | 1-4 × 22-30 mg/kg (mouse) | 3-24 h | [113,136,137,138,139,141,142,143] |
| 1 × 100-350 mg/kg (rat) | 4-24 h | [144] | |
| TNF-α | 300 μg/kg or viral overexpression (mouse) | 2-96 h or 3 days | [145,146] |
| AP/1649, AP/1897 | 4 × 27 mg/kg (mouse) | 3-24 h | [143] |
| Other | |||
| Radiation | 8-18 Gy single dose or fractionated (rat) | 2-25 days | [147,148] |
| 20 Gy single dose or fractionated (mouse) | 3-120 h | [32] | |
| Photosensitizers | |||
| Bacteriochlorophyll-serine | 1 × 20 mg/kg (mouse) | 1-24 h | [136,149] |
| Targeted chemotherapy | |||
| MBT-0206 | 3 × 5 mg/kg (hamster) | 24 h | [150] |
| EndoTAG®-2 | 6 × 2.5 mg/kg (mouse) | 24 h | [151] |