Table 2.
Results for terbinafine and itraconazole.
| MLCCS | Diagnosis | Terbinafine | Itraconazole | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Obs | Exp | O/E | EBGM | GPS Signal | TreeScan p-value | Obs | Exp | O/E | EBGM | GPS Signal | TreeScan p-value | ||
| 05 | Mental Disorders | 0 | 0.6 | 0.0 | 1.3 | . | 0 | 0.1 | 0.0 | 1.4 | . | ||
| 06 | Diseases Of The Nervous System And Sense Organs | 37 | 22.7 | 1.6 | 1.6 | 0.28 | 11 | 5.2 | 2.1 | 1.7 | 0.54 | ||
| 07 | Diseases Of The Circulatory System | 51 | 44.4 | 1.1 | 1.2 | . | 21 | 10.2 | 2.1 | 1.7 | 0.13 | ||
| 07.01 | Hypertension | 1 | 2.0 | 0.5 | 1.3 | . | 1 | 0.6 | 1.8 | 1.5 | . | ||
| 07.02 | Diseases Of The Heart | 24 | 21.4 | 1.1 | 1.2 | . | 9 | 5.0 | 1.8 | 1.6 | . | ||
| 07.02.01 | Heart Valve Disorders | 1 | 2.8 | 0.4 | 1.2 | . | 0 | 0.7 | 0.0 | 1.3 | . | ||
| 07.02.03 | Acute Myocardial Infarction | 0 | 0.8 | 0.0 | 1.3 | . | 1 | 0.2 | 4.7 | 1.7 | . | ||
| 07.02.04 | Coronary Atherosclerosis And Other Heart Disease | 3 | 3.4 | 0.9 | 1.3 | . | 1 | 0.9 | 1.1 | 1.5 | . | ||
| 07.02.07 | Other And Ill-Defined Heart Disease | 3 | 1.0 | 3.1 | 1.7 | . | 3 | 0.2 | 12.3 | 3.9 | 0.09 | ||
| 07.02.08 | Conduction Disorders | 1 | 0.5 | 1.9 | 1.5 | . | 1 | 0.1 | 7.9 | 1.8 | . | ||
| 07.02.09 | Cardiac Dysrhythmias | 16 | 10.1 | 1.6 | 1.5 | . | 3 | 2.2 | 1.4 | 1.5 | . | ||
| 07.03 | Cerebrovascular Disease | 4 | 2.9 | 1.4 | 1.5 | . | 2 | 0.7 | 2.9 | 1.6 | . | ||
| 07.04 | Diseases Of Arteries; Arterioles; And Capillaries | 17 | 13.8 | 1.2 | 1.3 | . | 5 | 3.0 | 1.7 | 1.5 | . | ||
| 07.05 | Diseases Of Veins And Lymphatics | 5 | 4.3 | 1.2 | 1.4 | . | 4 | 0.9 | 4.4 | 1.9 | 0.47 | ||
| 09 | Diseases Of The Digestive System | 63 | 37.2 | 1.7 | 1.6 | 0.007 | 15 | 8.2 | 1.8 | 1.6 | 0.63 | ||
| 09.03 | Diseases Of Mouth; Excluding Dental | 5 | 3.3 | 1.5 | 1.5 | . | 0 | 0.7 | 0.0 | 1.3 | . | ||
| 09.04 | Upper Gastrointestinal Disorders | 8 | 7.2 | 1.1 | 1.3 | . | 5 | 1.5 | 3.3 | 1.8 | 0.53 | ||
| 09.06 | Lower Gastrointestinal Disorders | 1 | 0.8 | 1.3 | 1.5 | . | 1 | 0.2 | 5.8 | 1.7 | . | ||
| 09.07 | Biliary Tract Disease | 2 | 1.6 | 1.3 | 1.4 | . | 1 | 0.3 | 3.1 | 1.6 | . | ||
| 09.08 | Liver Disease | 14 | 3.1 | 4.5 | 3.5 | ** | 0.00005 | 1 | 0.7 | 1.4 | 1.5 | . | |
| 09.08.02 | Other Liver Diseases | 14 | 3.1 | 4.5 | 3.37 | ** | 0.00005 | 1 | 0.7 | 1.4 | 1.5 | . | |
| 09.08.02.04 | Other And Unspecified Liver Disorders | 14 | 2.8 | 5.1 | 4.1 | *** | 0.00002 | 1 | 0.6 | 1.6 | 1.5 | . | |
| 09.09 | Pancreatic Disorders (Not Diabetes) | 2 | 0.3 | 5.9 | 1.9 | . | 1 | 0.1 | 15.0 | 2.0 | . | ||
| 09.09.03 | Other Pancreatic Disorders | 2 | 0.1 | 36.9 | 4.2 | 0.06 | 1 | 0.0 | 69.3 | 2.2 | . | ||
| 09.10 | Gastrointestinal Hemorrhage | 12 | 6.4 | 1.9 | 1.6 | . | 2 | 1.5 | 1.4 | 1.5 | . | ||
| 09.12 | Other Gastrointestinal Disorders | 19 | 14.4 | 1.3 | 1.4 | . | 4 | 3.3 | 1.2 | 1.4 | . | ||
| 10 | Diseases Of The Genitourinary System | 29 | 23.5 | 1.2 | 1.3 | . | 1 | 5.5 | 0.2 | 0.4 | . | ||
| 11 | Complications Of Pregnancy; Childbirth; And The Puerperium | 0 | 0.6 | 0.0 | 1.2 | . | 1 | 0.1 | 8.1 | 1.7 | . | ||
| 12 | Diseases Of The Skin And Subcutaneous Tissue | 125 | 51.6 | 2.4 | 2.2 | ** | 0.00001 | 31 | 11.2 | 2.8 | 2.1 | ** | 0.00001 |
| 12.01 | Skin And Subcutaneous Tissue Infections | 4 | 3.7 | 1.1 | 1.4 | . | 3 | 0.9 | 3.5 | 1.7 | 0.84 | ||
| 12.02 | Other Inflammatory Condition Of Skin | 25 | 10.6 | 2.4 | 1.9 | 0.010 | 9 | 2.1 | 4.2 | 2.4 | 0.02 | ||
| 12.03 | Chronic Ulcer Of Skin | 1 | 0.3 | 3.6 | 1.6 | . | 0 | 0.1 | 0.0 | 1.5 | . | ||
| 12.04 | Other Skin Disorders | 95 | 37.0 | 2.6 | 2.3 | ** | 0.00001 | 19 | 8.1 | 2.3 | 1.8 | 0.05 | |
| 13 | Diseases Of The Musculoskeletal System And Connective Tissue | 60 | 43.3 | 1.4 | 1.4 | 0.59 | 15 | 9.1 | 1.7 | 1.6 | 0.84 | ||
| 13.01 | Infective Arthritis And Osteomyelitis (Except That Caused By TB Or STD | 1 | 0.3 | 3.6 | 1.6 | . | 4 | 0.1 | 56.8 | 19.5 | *** | 0.00001 | |
| 13.08 | Other Connective Tissue Disease | 59 | 42.7 | 1.4 | 1.4 | 0.63 | 11 | 8.9 | 1.2 | 1.4 | . | ||
| 16 | Injury And Poisoning | 2 | 0.8 | 2.6 | 1.6 | . | 0 | 0.2 | 0.0 | 1.4 | . | ||
| 17 | Symptoms; Signs; And Ill-Defined Conditions And Factors Influencing Health | 62 | 38.1 | 1.6 | 1.6 | 0.02 | 15 | 8.5 | 1.8 | 1.6 | 0.75 | ||
| 17.01 | Symptoms; Signs; And Ill-Defined Conditions | 62 | 38.1 | 1.6 | 1.6 | 0.02 | 15 | 8.5 | 1.8 | 1.6 | 0.75 | ||
| 17.01.01 | Syncope | 3 | 2.3 | 1.3 | 1.4 | . | 1 | 0.5 | 1.9 | 1.5 | . | ||
| 17.01.06 | Nausea And Vomiting | 10 | 3.9 | 2.6 | 1.9 | 0.42 | 6 | 0.9 | 6.4 | 3.5 | 0.03 | ||
| 17.01.07 | Abdominal Pain | 21 | 18.1 | 1.2 | 1.3 | . | 2 | 4.1 | 0.5 | 1.1 | . | ||
| 17.01.08 | Malaise And Fatigue | 3 | 2.9 | 1.0 | 1.4 | . | 1 | 0.7 | 1.5 | 1.5 | . | ||
| 17.01.09 | Allergic Reactions | 25 | 10.8 | 2.3 | 2.0 | 0.01 | 5 | 2.2 | 2.3 | 1.7 | . | ||
MLCCS = Multi-level Clinical Classifications System; Obs = Observed; Exp = Expected; O/E = Observed/Expected; TreeScan p = multiple testing adjusted p-values, p > 0.90 is indicated with ‘.’; EBGM: empirical Bayesian geometric mean; *** GPS Signal at lower 90% CI bound ≥2; ** Signal at lower 95% CI bound >1.5; Table includes (1) all major disease category headings; (2) any disease categories that signaled for GPS or with a p-value ≤ 0.10; (3) any parents/grandparent of categories that signaled, and (4) any sibling of a disease category that signaled as long as there were observed events. We excluded any categories that were exactly the same as the parent.