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. 2013 Jul 29;1(3):e00039. doi: 10.1002/phy2.39

Figure 2.

Figure 2

Characterization of the animal model. At 30 day postsurgery, thoracic aortuc constriction (TAC) induced pathological left ventricular hypertrophy and congestive HF in wild-type mice (W) and in FKBP12.6 overexpressing mice (K) of both genders (M for male; F for female). Sham-operated mice (S) were also studied at 30 days. (A), histograms showing the ratio of lung weight to tibia length in groups where pulmonary edema index was used to classify TAC mice into noncongested mice (C) or mice with congestive heart failure (H). (B), hypertrophic responses to TAC, (heart weight to tibia length as hypertrophy index) for mice of both genotypes and genders. Data are means ± SEM; *P < 0.05 TAC compared with Sham; $P < 0.05, mice with lung congestion (H) compared with mice without lung congestion (C).