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. 2013 Jul 29;1(3):e00039. doi: 10.1002/phy2.39

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© 2013 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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TAC-induced specific molecular signatures. Graphical representation of the most significant protein interaction networks using ingenuity pathway analysis (IPA) of differentially expressed identified proteins. The upregulated proteins are marked in red and the downregulated in green. The nodes represent proteins that are connected with one or several arrows; the solid arrows represent direct interactions and the dotted arrows indirect interactions. (A), the network shows the difference between noncongested (C) and nonfailing hearts (S), (B), the network demonstrates the difference between congestive failing hearts (H) and nonfailing hearts (S), (see Table 7). (C) Common bio-signature of TAC-induced pathological LVH: an IPA analysis shows that the TAC induces similar alterations in protein content in C and H mice. Upregulated identified proteins are depicted in red and downregulated identified proteins in green. Solid lines indicate direct interaction or regulation, and dashed lines indirect relationships.