Table 2.
Gravimetric data
| Female | Male | ||||||
|---|---|---|---|---|---|---|---|
| Genotype | Sham | TAC | Sham | TAC | |||
| FWS | FWC | FWH | MWS | MWC | MWH | ||
| W | Mice (n) | 4 | 4 | 4 | 4 | 4 | 4 |
| BW (g) | 20 ± 1 | 22 ± 1 | 22 ± 1 | 31 ± 1 | 28 ± 0.2 | 28.4 ± 1.4 | |
| LVW (mg) | 79 ± 3 | 116 ± 6* | 154 ± 9* | 112 ± 4† | 158 ± 4* | 171 ± 2* | |
| HW/TL (mg/mm) | 6.6 ± 0.3 | 8.8 ± 0.4* | 13 ± 1*$ | 8.4 ± 0.2 | 12 ± 0.4* | 13.0 ± 0.4* | |
| Lu W/TL (mg/mm) | 8.6 ± 0.5 | 8.8 ± 0.3 | 24 ± 4*$ | 9.1 ± 0.3 | 9.5 ± 0.6 | 18.1 ± 2.4*$ | |
| K | FKS | FKC | FKH | MKS | MKC | MKH | |
| Mice (n) | 4 | 4 | 4 | 4 | 4 | 4 | |
| BW (g) | 20 ± 1 | 23 ± 1 | 22 ± 1 | 28 ± 2 | 28 ± 1 | 25 ± 3 | |
| LVW(mg) | 73 ± 4 | 127 ± 10* | 179 ± 2* | 110 ± 10† | 154 ±15 | 181 ± 18* | |
| HW/TL (mg/mm) | 6.4 ± 0.4 | 9.9 ± 0.8* | 14 ± 0.3*$ | 8.5 ± 0.4 | 11 ± 1* | 13.9 ± 1.6*$ | |
| Lu W/TL (mg/mm) | 8.5 ± 0.5 | 9.9 ± 0.3* | 21 ± 3*$ | 8.7 ± 0.4 | 9.3 ± 0.2* | 14.4 ± 3.4*$ | |
Data are mean ± SEM. W, wild-type mice; K, FKBP12.6 overexpressing mice; S, sham-operated; TAC, thoracic aortic constriction; F, female; M, male; C, noncongested mice; H, mice with congestive heart failure; BW, body weight; LVW; left ventricle weight; HW/TL, ratio heart weight to tibia length; Lu/TL, ratio lung weight to tibia length. *P < 0.05 TAC versus sham; $P < 0.05 C versus H mice; †P < 0.05 female versus male.