Table 1.
IGF-IR promoter-binding proteins identified by MS in MCF7 and C4.12.5 cells.
| Protein Name | Coverage | Coverage | Source | |
|---|---|---|---|---|
| MCF7 | C4.12.5 | |||
| 4760598 | Adenylate kinase isozyme 2 | 4 | - | Mus musculus |
| 61743954 | AHNAK nucleoprotein isoform 1 | 1 | 3 | Homo sapiens |
| 1061128 | Anpg | 25 | 21 | Homo sapiens |
| 5453541 | Anterior gradient 2 homolog | 26 | − | Homo sapiens |
| 6753086 | Apurinic/apyrimidinic endonuclease 1 | 8 | − | Mus musculus |
| 10947139 | Arginase, type I | − | 3 | Homo sapiens |
| 6680748 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1 | 3 | 7 | Mus musculus |
| 10863945 | ATP-dependent DNA helicase II | 20 | 28 | Homo sapiens |
| 4503841 | ATP-dependent DNA helicase II, 70 kDa subunit | 22 | 28 | Homo sapiens |
| 1040689 | ATP-dependent DNA helicase Q1 (DNA-dependent ATPase Q1) | _ | 4 | Homo sapiens |
| 42740907 | Clusterin isoform 2 | − | 8 | Homo sapiens |
| 22208854 | Cytidine monophospho-N-acetylneuraminic acid synthetase | 3 | 3 | Mus musculus |
| 4557515 | Damage-specific DNA binding protein 2 (48kD) | 6 | 18 | Homo sapiens |
| 45476309 | Damage-specific DNA binding protein 2 splicing variant D4 | 7 | 13 | Homo sapiens |
| 4758138 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 | 15 | 13 | Homo sapiens |
| 506756 | Desmoyokin | − | 6 | |
| 1706481 | DNA ligase III | 23 | 37 | Homo sapiens |
| 11225260 | DNA topoisomerase I | 10 | 11 | Homo sapiens |
| 347019 | DnaK-type molecular chaperone hsp72-ps1 | 8 | 10 | Rattus norvegicus |
| 1722884 | DNA-repair protein complementing XP-C cells | − | 6 | Drosophila melanogaster |
| 38201714 | ELAV-like 1 | 10 | − | Homo sapiens |
| 4503471 | Eukaryotic translation elongation factor 1 α 1 | 6 | 2 | Homo sapiens |
| 4503477 | Eukaryotic translation elongation factor 1 β 2 | 7 | − | Homo sapiens |
| 25453472 | Eukaryotic translation elongation factor 1 δ isoform 2 | 22 | − | Homo sapiens |
| 110625979 | Eukaryotic translation elongation factor 1 γ | 6 | − | Mus musculus |
| 37078458 | Far upstream element-binding protein 1 (FUSE-binding protein 1) | 11 | 13 | Mus musculus |
| 27806887 | Fusion (involved in t(12;16) in malignant liposarcoma) | 5 | _ | Bos taurus |
| 7669492 | Glyceraldehyde-3-phosphate dehydrogenase | 9 | − | Mus musculus |
| 74736618 | Grainyhead-like protein 2 homolog | − | 16 | Homo sapiens |
| 51316135 | GTP-binding nuclear protein Ran, testis-specific isoform | 10 | − | Rattus norvegicus |
| 4504517 | Heat shock 27kDa protein 1 | 33 | − | Homo sapiens |
| 2495339 | Heat shock 70 kDa protein 1B | 8 | 10 | Bos taurus |
| 8393547 | Heterogeneous nuclear ribonucleoprotein A1 | 13 | 11 | Rattus norvegicus |
| 14043072 | Heterogeneous nuclear ribonucleoprotein A2/B1 isoform B1 | 19 | 10 | Homo sapiens |
| 31559916 | Heterogeneous nuclear ribonucleoprotein A3 isoform a | 11 | 15 | Mus musculus |
| 55956919 | Heterogeneous nuclear ribonucleoprotein AB isoform a | 9 | 3 | Homo sapiens |
| 14249959 | Heterogeneous nuclear ribonucleoprotein C (C1/C2) | 10 | 2 | Homo sapiens |
| 870747 | Heterogeneous nuclear ribonucleoprotein D (hnRNP D) | 11 | 22 | Homo sapiens |
| 10946928 | Heterogeneous nuclear ribonucleoprotein H1 | 13 | 8 | Mus musculus |
| 14141157 | Heterogeneous nuclear ribonucleoprotein H3 isoform a | 11 | − | Homo sapiens |
| 13384620 | Heterogeneous nuclear ribonucleoprotein K | 23 | 10 | Mus musculus |
| 133274 | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | 4 | 4 | Homo sapiens |
| 14141152 | Heterogeneous nuclear ribonucleoprotein M isoform a | 15 | 18 | Homo sapiens |
| 5031755 | Heterogeneous nuclear ribonucleoprotein R isoform 2 | 6 | 6 | Homo sapiens |
| 8393536 | High mobility group box 2 | 14 | − | Rattus norvegicus |
| 1568557 | Histone H2B | 19 | 12 | Homo sapiens |
| 968888 | HMG-1 | 13 | − | Homo sapiens |
| 32358 | HnRNP U protein | 11 | 9 | Homo sapiens |
| 37183160 | HRPE773 | − | 29 | Homo sapiens |
| 1040689 | Human Diff6, H5, CDC10 homologue, KIAA0097 | 6 | − | Homo sapiens |
| 13385872 | Interleukin enhancer binding factor 2 | 8 | 13 | Mus musculus |
| 4504865 | KH-type splicing regulatory protein (FUSE binding protein 2) | 6 | 8 | Homo sapiens |
| 6453818 | Kinesin family member 22 | − | 20 | Homo sapiens |
| 2055427 | KSRP | 5 | 26 | Homo sapiens |
| 27436946 | Lamin A/C isoform 1 precursor | 20 | 15 | Homo sapiens |
| 5031877 | Lamin B1 | 8 | 21 | Homo sapiens |
| 14149645 | Methyl CpG binding protein 2 | 4 | 4 | Mus musculus |
| 1770458 | M-phase phosphoprotein 4 | 12 | 6 | Homo sapiens |
| 4038587 | Mucin | − | 2 | Homo sapiens |
| 55956788 | Nucleolin | 5 | 5 | Homo sapiens |
| 58037163 | Nucleoporin 35 | 6 | − | Mus musculus |
| 35119 | NuMA protein | − | 2 | Homo sapiens |
| 1483131 | p80 protein | 3 | 3 | Homo sapiens |
| 115497186 | Paraspeckle component 1 | 2 | 7 | Bos taurus |
| 156523968 | Poly (ADP-ribose)polymerase | 32 | 36 | Homo sapiens |
| 14141166 | Poly(rC)-binding protein 2 isoform b | 20 | 9 | Homo sapiens |
| 31543419 | Polynucleotide kinase 3 phosphatase | 13 | 11 | Homo sapiens |
| 4506243 | Polypyrimidine tract-binding protein 1 isoform a | 8 | 10 | Homo sapiens |
| 4502801 | Regulator of chromosome condensation (RCC1) | 12 | 10 | Homo sapiens |
| 4506583 | Replication protein A1, 70kDa | 18 | 26 | Homo sapiens |
| 4506585 | Replication protein A2, 32kDa | 7 | − | Homo sapiens |
| 4506439 | Retinoblastoma binding protein 7 | 3 | − | Homo sapiens |
| 15718687 | Ribosomal protein S3 | 23 | − | Homo sapiens |
| 7159943 | RNA and export factor binding protein 1-II | 24 | 9 | Mus musculus |
| 4757926 | RNA binding motif protein 39 isoform b | 3 | − | Homo sapiens |
| 66346679 | SERPINE1 mRNA binding protein 1 isoform 1 | 9 | 9 | Homo sapiens |
| 2440078 | SPIN protein | − | 4 | Homo sapiens |
| 4826998 | Splicing factor proline/glutamine rich | 9 | 11 | Homo sapiens |
| 5902076 | Splicing factor, arginine/serine-rich 1 isoform 1 | 4 | − | Homo sapiens |
| 39930517 | Sterile alpha motif domain containing 1 | 11 | 17 | Homo sapiens |
| 30088600 | Telomerase subunit EST1A | 1 | 1 | Homo sapiens |
| 4507555 | Thymopoietin isoform alpha | 8 | 17 | Homo sapiens |
| 4507401 | Transcription factor A, mitochondrial | 4 | - | Homo sapiens |
| 14389309 | Tubulin alpha 6 | 6 | 12 | Homo sapiens |
| 12963615 | Tubulin, beta 3 | 9 | 8 | Mus musculus |
| 21361322 | Tubulin, beta 4 | 9 | 9 | Homo sapiens |
| 1066004 | Typr II DNA topoisomerase beta isoform | − | 1 | Mus musculus |
| 28077011 | Tyrosyl-DNA phodphodiesterase 1 | 4 | 4 | Mus musculus |
| 4506387 | UV excision repair protein RAD23 homolog B | 4 | − | Homo sapiens |
| 2632123 | Xeroderma Pigmentosum Group E Complementing protein | 7 | 17 | Homo sapiens |
| 5454172 | X-ray repair cross complementing protein 1 | 9 | 12 | Homo sapiens |
Gi: identification tool; Coverage: percentage of amino acids covered by the identified peptide (n = 3 independent analyses).