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. Author manuscript; available in PMC: 2013 Nov 20.
Published in final edited form as: Gastroenterology. 2012 Nov 15;144(3):10.1053/j.gastro.2012.11.022. doi: 10.1053/j.gastro.2012.11.022

Figure 5. RYGB induces resistance to HFD-induced weight-gain.

Figure 5

(A) RYGB-treated MC4R-Het mice fail to gain weight upon challenge with HFD for 8 days compared to Sham mice. In contrast, Sham- and RYGB-treated MC4R-null mice gained substantial and equivalent weight (n=4-11/group) (B) Food intake was increased on HFD in RYGB-treated and Sham-operated mice of both genotypes (n=4-11/group). (C and D) Sham-operated MC4R-Het and MC4R-null mice and RYGB-treated MC4R-null mice assimilate all excess consumed energy on HFD as body mass at an elevated metabolic efficiency. Energy expenditure is reduced in Sham-operated MC4R-Het mice as a compensation for their weight gain on HFD. In contrast, RYGB-treated MC4R-Het mice fail to increase their metabolic efficiency on HFD. In addition, their elevated energy expenditure persists and remains elevated versus Sham MC4R-Het mice (n=4-11/group). *p<.05 RYGB vs. Sham or HFD vs. RC.