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. Author manuscript; available in PMC: 2014 Feb 19.
Published in final edited form as: Acc Chem Res. 2012 Oct 2;46(2):10.1021/ar300175n. doi: 10.1021/ar300175n

Figure 2.

Figure 2

A) Structure of one of the early dipeptide lead compounds, 1, that exhibits excellent isoform selectivity. B) and C) show the crystal structures of the dipeptide inhibitor 1 in the active site of eNOS (1P6L) and nNOS (1P6H). In nNOS the inhibitor “curls” which enables the inhibitor α-amino group to interact with both Glu592 and Asp597. In eNOS Asn368 is the homolog to nNOS Asp597.