Table 2. Differentially Expressed miRNAs and Characteristcs.
| Expression (CS vs PNC) | |||
|---|---|---|---|
|
|
|||
| miRNAs | Chromosome Locations | Array | qPCR |
| miR-181a | 1q32.1, 9q33.3 | Up | Not significant |
| miR-let7a | 9q22.3, 11q24.1, 22q13.31 | Down | Down |
| miR-100 | 11q24.1 | Down | Down |
| miR-222 | Xp11.3 | Down | Down |
| miR-136 | 14q32.2 | Down | Down |
| miR-376a | 14q32.31, 14q32.31 | Down | Down |
| miR-335 | 7q32.2 | Down | Down |
|
| |||
| Target Genes (Reported) | Functions | references | |
|
| |||
| SIRT1 | cell survival, defense against oxidative stress | 8, 9 | |
| Ras, HMGA2 | carcinogenesis | 10, 11 | |
| Myc | carcinogenesis | 12 | |
| PTEN | carcinogenesis | 13 | |
| Rb1, Versican | carcinogenesis | 14, 15 | |
| PIK3R1 | cell proliferation | 14, 18 | |
| SOX4, TNC | tumor metastasis | 19 | |