Table 1.
Baseline Characteristics of Women in Whom Coronary Heart Disease Developed During Follow‐up and Matched Controls in the NHS*
| Variable | Cases (n=397) | Controls (n=779) |
|---|---|---|
| Age, y | 60.1 (6.5) | 59.8 (6.6) |
| BMI, kg/m2 | 26.6 (5.4) | 25.1 (4.3) |
| Current smoker, % | 24 | 24 |
| Fasting >8 h, % | 75 | 73 |
| Alcohol intake (g/day), median (IQR) | 0.9 (0.0, 5.6) | 1.8 (0.0, 8.6) |
| Physical activity, METh/week | 18.2 (22.4) | 18.8 (19.7) |
| White ethnicity, % | 99 | 100 |
| Postmenopausal, % | 85 | 84 |
| Family history of MI, % | 22 | 13 |
| Diabetes,* % | 15 | 5.4 |
| Hypercholesterolemia,* % | 53 | 42 |
| Hypertension,* % | 51 | 29 |
| CVD biomarkers | ||
| Total cholesterol, mmol/L | 6.00 (1.04) | 5.87 (1.05) |
| LDL‐C, mmol/L | 3.71 (0.95) | 3.51 (0.97) |
| HDL‐C, mmol/L | 1.35 (0.39) | 1.54 (0.43) |
| Triglycerides (mmol/L), median (IQR) | 1.40 (0.99, 1.99) | 1.19 (0.86, 1.65) |
| CRP (g/L), median (IQR) | 0.26 (0.12, 0.55) | 0.19 (0.08, 0.38) |
| FlOP_360, median (IQR) | 229 (177, 307) | 216 (174, 277) |
| FlOP_320, median (IQR) | 412 (303, 712) | 380 (297, 594) |
| FlOP_400, median (IQR) | 64.6 (50.1, 89.8) | 61.0 (48.4, 83.6) |
BMI indicates body mass index; CRP, C‐reactive protein; CVD, cardiovascular disease; FlOP, fluorescent oxidation product; HDL‐C, high‐density lipoprotein cholesterol; IQR, interquartile range; LDL‐C, low‐density lipoprotein cholesterol; METh/week, metabolic equivalent hours per week; MI, myocardial infarction; NHS, Nurses' Health Study.
Data are presented as means (SDs) unless otherwise indicated. Matching criteria were age, smoking, date of blood sampling, and fasting status. FlOPs are presented as relative fluorescent intensity/mL of plasma. To convert cholesterol concentrations from mmol/L to mg/dL, divide by 0.0259. To convert triglycerides from mmol/L to mg/dL, divide by 0.0113.
Self‐reported diagnosis before blood draw.