Table 4.
High and Low Expressed Genes in Right Atrial hMSCs Compared With Subcutaneous Fat hMSCs
| Gene Name | Full Name | Function | Fold Change |
|---|---|---|---|
| Highly expressed genes in right atrial hMSCs compared with subcutaneous fat hMSCs | |||
| TGFB2 | Transforming growth factor‐β2 | Suppressive effects on T‐cell growth | 5.21 |
| C3 | Complement component 3 | Plays a central role in the activation of the complement system | 4.17 |
| CFB | Complement factor B | Regulation of the immune reaction | 3.71 |
| IL1B | Interleukin 1β | Mediators of inflammatory response | 3.47 |
| IL32 | Interleukin 32 | Induces the production of TNFα and IL‐8 from macrophages | 3.37 |
| TLR4 | Toll‐like receptor 4 | Leads to cytokine secretion and inflammatory responses. | 3.21 |
| CSF3 | Colony stimulating factor 3 | Controls production, differentiation, and function of granulocytes | 3.18 |
| ICAM1 | Intercellular adhesion molecule 1 | Leukocyte adhesion and migration | 3.08 |
| GATA4 | GATA binding protein 4 | Involved in myocardial differentiation and function | 3.01 |
| CFH | Complement factor H | Regulation of the immune reaction | 3.00 |
| BMP4 | Bone morphogenetic protein 4 | Growth and differentiation factor | 2.90 |
| TNFA‐IP3 | Tumor necrosis factor‐α–induced protein 3 | Involved in cytokine‐mediated immune and inflammatory responses | 2.72 |
| TNFAIP6 | Tumor necrosis factor‐α–induced protein 6 | Associated with cell–cell and cell–matrix interactions during inflammation | 2.63 |
| GDF15 | Growth differentiation factor 15 | Upregulated on stress, biomarkers of heart damage, inhibits macrophages. | 2.26 |
| TNFRSF21 | Tumor necrosis factor receptor superfamily21 | Induces cell apoptosis, involved in inflammation and immune regulation | 2.22 |
| CXCL6 | Chemokine (C‐X‐C motif) ligand 6 | Chemotactic for neutrophil granulocytes | 2.10 |
| CXCL12 | Chemokine (C‐X‐C motif) ligand 12 | Chemoattractant active on T cells and monocytes, protective role after myocardial infarction | 2.10 |
| BMP6 | Bone morphogenetic protein 6 | Growth and differentiation factor | 2.08 |
| Low expressed genes in right atrial hMSCs compared with subcutaneous fat hMSCs | |||
| IL13RA2 | Interleukin 13 receptor α2 | Plays a role in the internalization of IL‐13 | −4.87 |
| CCRL1 | Chemokine (C‐C motif) receptor‐like 1 | Receptor for C‐C type chemokines | −4.07 |
| KITLG | KIT ligand, stem cell factor | Ligand of the c‐kit receptor, stem cell maintenance | −3.47 |
| CD109 | CD109 molecule | Modulates negatively TGFβ1 signaling | |
| WNT5A | Wingless‐type MMTV integration site family 5A | Activation of noncanonical Wnt signaling, inhibition of canonical Wnt signaling | −3.07 |
| FGF7 | Fibroblast growth factor 7 | Regulation of cell proliferation and differentiation | −2.86 |
| CLU | Clusterin | Protects cells against apoptosis, regulates cell proliferation | −2.84 |
| TGFBR3 | Transforming growth factor‐β receptor III | Binds to TGFβ | −2.77 |
| LY6K | Lymphocyte antigen 6K | May play a role in cell growth | −2.56 |
hMSCs indicate human mesenchymal stromal cells; TGF, transforming growth factor; IL, interleukin.