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. 2013 Oct 25;2(5):e000386. doi: 10.1161/JAHA.113.000386

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© 2013 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an Open Access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 9. — Composition of loop A in Imp α1 and α5 and its effect on docking of N50 to the major NLS binding pocket. A and B, Ribbon structure and composition of loop A of (A) human Imp α1 (KPNA2), and (B) human Imp α5 (KPNA1). Structures were visualized in DeepView. C and D, 3‐D models of p50 NLS docking to the molecular surface of (C) human Imp α1 (KPNA2), and (D) human Imp α5 (KPNA1). Please note that loop A may provide stability to the p50 NLS‐Imp α5 complex while no such role is apparent for loop A in Imp α1. Docking models were generated by AutoDock Vina 1.1.2 and visualized by PythonMoleculeViewer 1.5.6. Imp α indicates importin α; NLS, nuclear localization sequence.