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. 2013 Oct 25;2(5):e000402. doi: 10.1161/JAHA.113.000402

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© 2013 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an Open Access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 3. — Quantitative MRI and histological analysis. A, R₁ increased in atherosclerotic ApoE^−/− mice and decreased in the minocycline‐ and ebselen‐treated animals. B, ICP‐MS calculation of gadolinium concentration within the vessel wall. C, Contrast‐enhanced vessel wall area. D, Histological assessment of plaque burden. P values between groups relate to an ANOVA test with a Bonferroni correction (for A and C) and to a Kruskal–Wallis test followed by a Dunn's post hoc test (for B and D). ANOVA indicates analysis of variance; HFD, high‐fat diet; ICP‐MS, inductively coupled mass spectrometry; MRI, magnetic resonance imaging.