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Smooth muscle ROCK maintains resting tone and mediates ET-1–induced constriction. (A) Control (n = 7) and denuded (n = 6) vessels with resting tone were treated with increasing concentrations of H-1152 for 5 minutes at each concentration. (B) Control (n = 7) and denuded (n = 7) vessels with resting tone were treated with ET-1 (0.1 nM) for 20 minutes to produce vasoconstriction, followed by administration of H-1152 (3 μM) for 20 minutes. *P < 0.05 versus resting diameter at 0 minutes.
