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. 2013 Nov 15;54(12):7587–7594. doi: 10.1167/iovs13-13178

Figure 5.

Figure 5

Role of endothelium in PKC activation-induced vasomotor activity. (A) Control (n = 7) and denuded (n = 7) vessels with resting tone were treated with PDBu (0.1 μM) for 20 minutes, followed by incubation with H-1152 (3 μM) for 20 minutes. *P < 0.05 versus resting diameter at 0 minutes. #P < 0.05 versus diameter at time of H-1152 addition (20 minutes). (B) Pretreatment of control (n = 7) and denuded (n = 7) vessels with nifedipine (1 μM) for 20 minutes was followed by PDBu (0.1 μM) treatment for 20 minutes. In another set of experiments, control vessels were pretreated with nifedipine plus L-NAME (10 μM, n = 3) before administration of PDBu. *P < 0.05 versus resting diameter at 0 minutes. #P < 0.05, diameter at 40 minutes versus diameter at 20 minutes.