Figure 2.
APL-OSA associations. APL-OSA associations after restricting initial analyses (Fig. 1) based on a liberal P value (P < 0.15). It is these associations that are used throughout the paper as they represent our best estimation of the gene–smoking interactions. In the LocusZoom (Pruim et al. 2010) plot the −log10(P value) is given on the y-axis and the genomic location on the x-axis. Only the area under the chromosome 3 linkage peak (Hauser et al. 2004) is shown. Colors indicate the linkage disequilibrium with the most significant SNP in KALRN (rs4234218, shown as a diamond) and are based on LD within the CEU HapMap population. Only rs2272486 (arrow) shows even modest LD (color figure online)