. Author manuscript; available in PMC: 2013 Nov 20.

Published in final edited form as: J Nucl Med. 2012 Feb 6;53(3):10.2967/jnumed.111.097162. doi: 10.2967/jnumed.111.097162

TABLE 1.

Regional V_T of ¹¹C-NOP-1A in Human Brain Determined from Large VOIs or from Individual Voxels

	V_T (mL cm⁻³)

	VOI			Voxel

Brain region	Two-tissue	Logan_VOI	MA1_VOI	Logan_voxel	MA1_voxel
Temporal cortex	10.1 ± 1.6	9.6 ± 1.6	9.5 ± 1.5	8.9 ± 1.7	9.4 ± 1.8

Cingulate cortex	9.4 ± 1.5	8.9 ± 1.5	8.9 ± 1.5	8.3 ± 1.5	8.8 ± 1.6

Putamen	10.0 ± 1.8	9.5 ± 1.7	9.4 ± 1.7	8.9 ± 1.7	9.3 ± 1.8

Thalamus	9.0 ± 1.6	8.5 ± 1.5	8.5 ± 1.5	8.0 ± 1.6	8.5 ± 1.6

Cerebellum	5.6 ± 0.8	5.2 ± 0.8	5.3 ± 0.8	4.8 ± 1.0	5.1 ± 1.0

Values are mean ± SD from 7 humans using 120 min of brain and plasma data. Two-tissue-compartment model was fit with no constraints. Subscript “VOI” denotes that concentration of radioactivity from large VOIs (e.g., entire temporal cortex of 251 cm³) was analyzed. Subscript “voxel” denotes that concentration of radioactivity of individual voxel (8 mm³) was analyzed. Voxels of resulting parametric image have values equal to V_T.