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. 2013 Nov 20;8(11):e80700. doi: 10.1371/journal.pone.0080700

Figure 1. Soluble Aβ42 levels and β-secretase activity increase with respect to disease severity in the temporal cortex of AD brain.

Figure 1

(A) Aβ42-ELISA measurements reveal a significant increase in the soluble Aβ42 levels in the severe group of temporal cortex samples as compared to the mild and moderate groups (***p<0.001, *p<0.05, ANOVA, LSD, mild n = 43; moderate n = 12; severe n = 27). (B) β-secretase activity assay indicates a significant increase in β-secretase activity in both moderate and severe groups as compared to the mild group of temporal cortex samples (***p<0.001, *p<0.05, ANOVA, LSD, mild n = 43; moderate n = 12; severe n = 27). (C) Soluble Aβ42 levels and β-secretase activity in the temporal cortex samples show significant correlation (p<0.01, Pearson two-tailed correlation, n = 85).