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. 2013 Nov 20;8(11):e80700. doi: 10.1371/journal.pone.0080700

Figure 2. Aβ42 levels in the CSF decrease while tot-tau and p-tau levels increase with respect to disease progression in AD temporal cortex.

Figure 2

(A) CSF Aβ42 levels are significantly decreased in both moderate and severe groups as compared to the mild group (**p<0.01, *p<0.05, ANOVA, LSD, mild n = 9; moderate n = 4; severe n = 15). (B) CSF Aβ42 levels and soluble Aβ42 levels indicate a significant negative correlation in the temporal cortex samples (p<0.01, Pearson two-tailed correlation, n = 26). (C) CSF tot-tau levels are significantly increased in the severe group as compared to the mild and moderate groups (***p<0.001, *p<0.05, ANOVA, LSD, mild n = 8; moderate n = 4; severe n = 14). (D) The p-tau levels in the CSF are significantly increased in the severe group as compared to the mild group (*p<0.05, ANOVA, LSD, mild n = 8; moderate n = 4; severe n = 14). Mean values are indicated in the graphs and each dot represents one individual.