Table 1. Patient characteristics stratified by HPV positivity and primary tumor sites a .
| Total | HPV-positive patients† | HPV-negative patientsb | p-value | |||||
|---|---|---|---|---|---|---|---|---|
| n=248 | n=27 | n=221 | ||||||
| Sino-nasal | Oropharynx | Hypopharynx | Larynx | Oral cavity | ||||
| n=23 | n=41 | n=65 | n=33 | n=59 | ||||
| Age, years – yr. mean ± s.d. | 63.2±11.0 | 58.6±10.1 | 61.7±12.8 | 65.2±11.3 | 66.9±6.7 | 66.3±10.6 | 58.7±12.5 | 0.0001 c |
| Women – no. (%) | 51 (21) | 6 (22) | 7 (30) | 6 (15) | 9 (14) | 3 (9) | 20 (34) | 0.022 d |
| Stage – no. (%) | < 0.001 d | |||||||
| I | 17 (7) | 0 (0) | 0 (0) | 1 (2) | 3 (5) | 5 (15) | 8 (14) | |
| II | 49 (20) | 4 (15) | 2 (9) | 14 (34) | 8 (12) | 5 (15) | 16 (28) | |
| III | 52 (21) | 5 (19) | 10 (43) | 9 (22) | 8 (12) | 7 (21) | 13 (23) | |
| IV | 128 (52) | 18 (67) | 11 (48) | 17 (41) | 46 (71) | 16 (48) | 20 (35) | |
| Cell differentiation – no. (%) | ||||||||
| Well differentiated | 74 (31) | 5 (19) | 7 (32) | 8 (20) | 11 (18) | 15 (48) | 28 (50) | 0.001 d |
| Moderately differentiated | 118 (49) | 16 (59) | 8 (36) | 25 (61) | 34 (55) | 11 (35) | 24 (43) | |
| Poorly differentiated | 47 (20) | 6 (22) | 7 (32) | 8 (20) | 17 (27) | 5 (16) | 4 (7) | |
| Second primary cancers | 48 (19) | 3 (11) | 2 (9) | 16 (39) | 19 (29) | 2 (6) | 6 (10) | < 0.001 d |
| Tobacco smoke | ||||||||
| Pack-year – median (IQR e ) | 25 (0 - 40) | 10 (0 - 30) | 19 (0 - 40) | 30 (20 - 50) | 32 (5 - 49) | 40 (14 - 40) | 15 (0 - 40) | 0.0006 f |
| Smoking status – no. (%) | < 0.001 d | |||||||
| Non-smoker | 71 (29) | 11 (41) | 9 (41) | 5 (12) | 16 (25) | 4 (12) | 26 (44) | |
| Moderate smoker | 28 (11) | 7 (26) | 2 (9) | 5 (12) | 1 (2) | 6 (18) | 7 (12) | |
| Heavy smoker | 147 (60) | 9 (33) | 11 (50) | 31 (76) | 47 (73) | 23 (70) | 26 (44) | |
| Drinking status – no. (%) | 0.015 d | |||||||
| Non-drinker | 93 (38) | 14 (52) | 10 (45) | 14 (34) | 17 (26) | 11 (33) | 27 (46) | |
| Moderate drinker | 77 (31) | 2 (7) | 9 (41) | 13 (32) | 19 (29) | 14 (42) | 20 (34) | |
| Heavy drinker | 77 (31) | 11 (41) | 3 (14) | 14 (34) | 29 (45) | 8 (24) | 12 (20) | |
| Smoking/drinking – no. (%) | 0.001 d | |||||||
| Non-smoker non-drinker | 53 (22) | 8 (30) | 8 (38) | 4 (10) | 10 (16) | 3 (9) | 20 (34) | |
| Smoker but non-drinker | 39 (16) | 6 (22) | 2 (10) | 10 (24) | 6 (9) | 8 (24) | 7 (12) | |
| Drinker but non-smoker | 18 (7) | 3 (11) | 1 (5) | 1 (2) | 6 (9) | 1 (3) | 6 (10) | |
| Both smoker and drinker | 135 (55) | 10 (37) | 10 (48) | 26 (63) | 42 (66) | 21 (64) | 26 (44) | |
| TP53 mutations – no. (%) | 0.001 d | |||||||
| Wild-type TP53 | 87 (37) | 18 (69) | 9 (43) | 9 (23) | 15 (23) | 12 (41) | 24 (44) | |
| Non-disruptive TP53 | 94 (40) | 5 (19) | 6 (29) | 15 (38) | 36 (56) | 13 (45) | 19 (35 | |
| Disruptive TP53 | 53 (23) | 3 (12) | 6 (29) | 15 (38) | 13 (20) | 4 (14) | 12 (21) |
a
Because of rounding, the sum of totals is not always 100%. Patients with non-squamous cell cancer or unknown primary sites were excluded. Smoking and drinking status were unknown in 3 patients.
b
A total of 248 patients were stratified into HPV-positive patients and HPV-negative patients. Then, HPV-negative patients were divided by the primary sites.
c
P-value was calculated by ANOVA.
d
P-value was calculated by χ2 test.
e
Interquartile range
f
Kruskal-Wallis equality-of-populations rank test