Table 2. Effects of alcohol drinking on SCNAs, TP53 mutations in HPV-negative patients.

		Alcohol drinkers		Heavy drinkers vs. moderate ~ non-drinkers		Drinkers vs. non-drinkers
	None	Moderate	Heavy	RR (95%CI)	p-value	RR (95%CI)	p-value
	N=72	N=66	N=61	RD (95%CI)		RD (95%CI)
CDKN2A a gene deletions: 1 copy or 0 copy – no. (%) total: 49 (25%)	12 (17)	10 (15)	27 (44)	2.78 (1.73 to 4.47)	< 0.0001	1.75 (0.98 to 3.31)	0.050
				0.28 (0.14 to 0.42)		0.12 (0.01 to 0.24)
Homogeneous deletion of CDKN2A gene:0 copy – no. (%) total: 12 (6%)	1 (1)	1 (2)	10 (16)	11.31 (2.55 to 50.1)	< 0.0001	6.24 (0.82 to 47.3)	0.038
				0.15 (0.05 to 0.24)		0.08 (0.07 to 0.17)
ERBB2 b amplification: 4 copies ≤ –no. (%) total: 12 (6%)	0 (0)	4 (6)	8 (13)	4.52 (1.42 to 14.5)	0.005	-	0.007
				0.10 (0.01 to 0.19)		0.09 (0.04 to 0.15)
FHITc gene deletions: 1 copy or 0 copy – no. (%) total: 42 (21%)	8 (11)	14 (21)	20 (33)	2.06 (1.22 to 3.48)	0.007	2.41 (1.18 to 4.92)	0.009
				0.17 (0.04 to 0.30)		0.16 (0.05 to 0.26)
CSMD1 d gene deletions: 1 copy or 0 copy – no. (%) total: 38 (19%)	7 (10)	9 (14)	22 (36)	3.11 (1.76 to 5.50)	0.0001	2.51 (1.17 to 5.40)	0.011
				0.24 (0.11 to 0.38)		0.15 (0.05 to 0.25)
PIK3CAe amplification: 3 copies ≤ – no. (%) total: 92 (47%)	30 (42)	25 (39)	37 (64)	1.58 (1.19 to 2.09)	0.003	1.22 (0.88 to 1.69)	0.22
				0.23 (0.08 to 0.38)		0.09 (-0.05 to 0.24)
CCND1 f amplification: 4 copies ≤ – no. (%) total: 39 (20%)	10 (14)	11 (17)	18 (30)	1.94 (1.12 to 3.37)	0.019	1.64 (0.85 to 3.17)	0.13
				0.14 (0.01 to 0.27)		0.09 (-0.02 to 0.20)
TP53 mutation – no. (%) Total: 139 (67%)	45 (60)	54 (75)	40 (66)	0.97 (0.79 to 1.21)	0.80	1.18 (0.95 to 1.46)	0.12
				-0.02 (-0.16 to 0.12)		0.11 (-0.03 to 0.24)

^aCDKN2A: cyclin-dependent kinase inhibitor 2A

^bERBB2: v-ERB-B2 avian erythroblastic leukemia viral oncogene homologue2

^cFHIT: fragile histidine triad gene

^dCSMD1: cub and sushi multiple domains1

^ePIK3CA: phosphatidylinositol3-kinase catalytic alpha (q=0.014)

^fCCND1: cyclin D1