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. 2013 Nov 20;8(11):e81382. doi: 10.1371/journal.pone.0081382

Figure 2. Collagen monomers increase M2 marker production by AM.

Figure 2

M2 cytokine production of BAL cells stimulated with monomers of various collagen types. M2 cytokine production of BAL cells from 5 additional patients with IPF are depicted in black and 5 additional experiments with BAL cells from healthy donors are depicted in grey. Panel A shows CCL18 production following stimulation with rat collagen-I (Col 1R; 100µg/ml), human collagen-I (Col I, 100 µg/ml), human collagen-III (Col III, 100 µg/ml), human collagen-IV (Col IV, 100 µg/ml), human collagen-V (Col V, 100 µg/ml). Panel B shows IL-1ra production following the same stimulation protocol. Panel C shows CCL2 production. *p<0.05.