Effects of KR62776 on the levels of the cell cyclerelated proteins in HSC-T6 cells. Cell lysate proteins (20 μg/lane) were separated on 10% SDS-polyacrylamide gels and subjected to immunoblot analysis with the specific antibody against p21, p27, GADD45, cyclin D1, cdk2, cyclin B, or GAPDH, followed by incubation with a horseradish peroxi-dase-conjugated secondary antibody. Detection of each antigen was performed using the ECL detection kit. The results shown are representative blots of three independent experiments.