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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Br J Haematol. 2013 Sep 6;163(3):10.1111/bjh.12542. doi: 10.1111/bjh.12542

Figure 4. Incidence and time course of renal impairment.

Figure 4

A. Mean estimated glomerular filtration rate (GFR) at initial presentation in those with normal or elevated lactate dehydrogenase (LDH). The horizontal line represents the mean, the box represents the 25th–75th percentile, and the bars represent the minimum and maximum values. LDH <2x upper limit of normal (ULN) vs. LDH ≥2x ULN, p < 0.0001 (unpaired t test). B. Mean estimated GFR at initial presentation in all analysis groups. P value calculated with the unpaired t test. Group B LDH <2x ULN vs. LDH ≥2x ULN, p < 0.002 (unpaired t test). Group C LDH <2x ULN vs. LDH ≥2x ULN, p < 0.015 (unpaired t test). C. Mean estimated GFR at initial presentation in those with normal or elevated uric acid (UA). UA <475.8 μmol/l vs. ≥475.8 μmol/l p = 0.0003. D. Mean estimated GFR for patients with initial GFR < 60 ml/min/1.73m2 over the observation period. The box and whiskers are defined as in (a). The dashed line represents a GFR of 60 ml/min/1.73m2. P = 0.0007 (unpaired t test) comparing day −1 to day 7. E. Daily estimated GFR for individual patients with renal impairment any time before COP-R (cyclophosphamide, vincristine, prednisone, rituximab). The dashed line indicates 60 ml/min/1.73m2.