Figure 3.

Changes in CA-125, HE4, and 14-3-3 zeta protein serum levels, and ROMA index values during the six cycles of paclitaxel/carboplatin-based chemotherapy that were performed. Mean concentrations of CA-125 determined by ELISA (A) and by ECLIA (D) are shown for each of the treatment days. Mean levels of HE4 determined by ELISA (B) and ECLIA (E) are also shown for each of the treatment days. Mean concentrations of 14-3-3 zeta protein were determined by ELISA (G) are represented at each chemotherapy days. Postmenopausal ROMA index values were calculated based on ELISA (C) and ECLIA (F) data. Linear regression analysis was performed for each diagram (see r value), and statistical significance was set at p < 0.05.