Figure 10. Concurrent transcriptional regulation of Myh7b/miR499 by Hltf.

Diagram showing Hltf-regulatory routes (A). Sequence of the Myh7b/miR499 promoter shows authentic transcription factor binding sites (B). Putative Hltf binding elements (red) are three of five highly conserved binding sites previously described as ‘unknown’ [37]. Hltf binding to this shared promoter was authenticated by ChIP-PCR (Figure 2, Panel B). The authentic Gata4 binding site (red) is indicated as Hltf regulates transcriptional availability of Gata4.