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. 2013 Nov 20;8(11):e80461. doi: 10.1371/journal.pone.0080461

Table 5. Downregulated (p<0.05) contributors to the cardiac phenotype.

Gene name Fold-change Function
Actg1 1.76 Striations in cardiomyocytes
Adam12 1.90 Myoblast fusion
Adam17 2.16 Valvulogenesis
Adam19 2.23 Valvuloseptal morphogenesis
Adamts1 2.25 Stops trabeculation & compaction ventricular myocardium
Adamts9 2.22 Valvulogenesis
Cald1 2.07 Regulates smooth muscle contraction
Glut1 (Slc2a1) 2.28 Insulin-dependent glucose transporter
Hand1 4.19 Cardiac morphogenesis
Hk2 2.38 Catalyzes first step in glucose metabolism; antiapoptotic
Hif1a 2.34 Mediates cardioprotection
Icam1 2.26 Aortic valvulogenesis
Loxl2 2.45 Crosslinks elastin and collagen in ECM
Nfkb2 2.19 Induces angiogenesis; antiapoptotic
P4ha1 2.14 Required for collagen deposition
P4ha2 2.51 Required for collagen deposition
Plod2 2.43 ECM stiffening; collagen fiber alignment
Ppid 2.71 Accelerates collagen folding
Ppif 2.17 Accelerates collagen folding
Ppil3 2.57 Molecular chaperone in protein-folding
Prrx2 3.11 Coronary vascular morphogenesis
Snai1 1.92 Induces EMT
Snal2 (Slug) 1.81 Induces EMT; antiapoptotic
Vcam1 2.29 Cardiomyocyte differentiation; aortic valvulogenesis
Vcan 2.16 Interventricular septal formation
Vegfa 2.57 Induces angiogenesis and vasculogenesis; antiapoptotic
Wt1 1.79 Induces epicardial EMT
Zeb1 2.46 Induces EMT