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. 2013 Nov 20;8(11):e81068. doi: 10.1371/journal.pone.0081068

Figure 2. Stapled peptides inhibit wild-type and mutant HDM2 function in p53/MDM2-null DKO cells.

Figure 2

A, Wild-type and indicated HDM2 mutants were co-transfected with p53 and p53 reporter gene activity (expressed as percentage of activity observed with p53-only transfection) measured in the presence of Nutlin (0/5/10 µM) and the stapled peptides PM2CON,PM2 and MO11 (10/20 µM). Data represents mean ± SD (n=2). B, Western blots indicating expression levels of HDM2 variants and p53 co-transfected into DKO cells.