Table 4.
Univariate and multivariate analysis of preoperative and operative factors as well as postoperative blood tests associated with 90-day mortality following liver resection in 495 patients.
| n = 495 | Univariate |
Multivariate | ||
|---|---|---|---|---|
| Factor (preoperative and operative factors and postoperative blood tests) | Coef (95% CI) | P value | Coef (95% CI) | P value |
| Age | 1.05 (1.01–1.10) | 0.029* | 0.194 | |
| Gender | 2.36 (0.91–6.08) | 0.077* | 0.196 | |
| Pathology | 0.274 | |||
| Liver directed chemotherapy | 0.356 | |||
| Diabetic | 3.09 (1.16–8.20) | 0.024* | 3.41 (1.14–10.23) | 0.028** |
| BMI | 0.444 | |||
| ASA grade | ||||
| 1 versus 2 | 3.02 (0.70–13.11) | 0.139* | 0.678 | |
| 2 versus 3 | 0.724 | |||
| Physiologic score | 1.12 (1.03–1.22) | 0.010* | 0.544 | |
| Operative score | 0.303 | |||
| P-POSSUM mortality | 1.04 (1.01–1.07) | 0.010* | 0.479 | |
| Fibrosis/cirrhosis | 0.986 | |||
| Preoperative bilirubin | 1.01 (1.00–1.03) | 0.081* | 0.652 | |
| Preoperative haemoglobin | 0.71 (0.55–0.93) | 0.012* | 0.195 | |
| Preoperative white cell count | 0.388 | |||
| Preoperative albumin | 0.90 (0.84–0.96) | 0.002* | 0.168 | |
| Preoperative alkaline phosphatase | 0.884 | |||
| Preoperative creatinine | 1.01 (1.00–1.02) | 0.098* | 0.764 | |
| Preoperative neutrophil lymphocyte ratio | 1.13 (0.98–1.31) | 0.086* | 0.366 | |
| Preoperative neutrophil lymphocyte ratio >5 | 2.18 (0.78–6.11) | 0.138* | 0.345 | |
| Open or laparoscopic resection | 0.987 | |||
| Radiofrequency ablation (RFA) included | 0.991 | |||
| Wedge resection included | 0.588 | |||
| Bile duct reconstruction included | 2.96 (1.05–8.39) | 0.041* | 0.383 | |
| Synchronous bowel procedure | 0.346 | |||
| Operation number | 0.549 | |||
| Number of segments resected | 1.59 (1.18–2.14) | 0.003* | 0.075 | |
| Number of procedures | 0.786 | |||
| Surgeons assessment of liver parenchyma | 2.14 (0.92–4.96) | 0.076* | 0.494 | |
| Blood loss (mL) | ||||
| <500 versus >500 | 2.67 (1.27–5.61) | 0.009* | 0.716 | |
| >500 versus >1000 | 0.652 | |||
| Units of red cells transfused | 1.13 (1.02–1.26) | 0.023* | 0.224 | |
| PHLF at POD 5 | 1.02 (1.01–1.03) | <0.001* | 4.51 (1.42–14.40) | 0.011** |
| Renal dysfunction (creatinine rise >1.5x) | 1.02 (1.01–1.03) | <0.001* | 3.63 (1.13–11.66) | 0.030** |
*Significant at the level of 0.25 for univariate analysis and included in multivariate analysis.
**Significant at the level of 0.05 for multivariate analysis.