Figure 2.

Antinociceptive effects of rutin and quercetin on oxaliplatin-induced mechanical nociceptive threshold decrease (von Frey). The mice received two intravenous injections of oxaliplatin (OXL; 1 mg/kg) per week, for 4.5 weeks for a total of nine injections. Rutin (A) and quercetin (B) were injected intraperitoneally 30 min before every OXL administration. The control group received saline instead of rutin or quercetin. Mechanical threshold was assessed before and every 7 days after each treatment. The data points represent the mean ± SEM the paw withdrawal response in grams (g) in six animals.*p < 0.05, **p < 0.01, ***p < 0.001 (ANOVA followed by Student Newman-Keuls post hoc test).