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. Author manuscript; available in PMC: 2013 Nov 21.
Published in final edited form as: Medchemcomm. 2013;4(11):10.1039/C3MD00185G. doi: 10.1039/C3MD00185G

Scheme-2. Synthetic scheme for preparation of NOSH-Sulindac (AVT-18A).

Scheme-2

a. TBDMSCl/Imidazole, DCM, 18h; b. 4-bromobutyric acid,DCC/DMAP, DCM, rt, 6h; c. AgNO3/acetonitrile, 70°C, 6h; d. NaH2PO4, H2O2/NaClO2, 0°C, 2h; e. ADT-OH, DCC/DMAP, DCM, rt, 6h; f. TBAF/AcOH, THF, 30 min; g. Sulindac, DCC/DMAP, DCM, rt, 6h.