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(A) Data from viscosity experiment were fit to Kramer's model (eq 16), ln(kcat) is linearly dependent on ln (ηrel) with a slope of -0.76 (R2 =0.93), indicating a strong coupling of product release with the active site conformational change. (B) The C-termini of hH1 homodimer that is proposed to undergo conformational change coupled with AMP release. The active sites are shown in pink and the C-termini are shown in red.
