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. 2013 Nov 20;8(11):e79466. doi: 10.1371/journal.pone.0079466

Table 4. Association of NOS3 genotype and diabetes case status in African Americans stratified by obesity.

Variable Genotype BMI kg/m2 n OR 95% CI p
All 3,737
Obesity(BMI ≥30 kg/m2) 2.53 2.13–3.01 <0.001
Interaction1 0.47 0.11–2.06 0.32
G894T GG ** ** **
GT 0.91 0.74–1.12 0.37
TT 0.79 0.38–1.63 0.52
<30 2,236
G894T GG ** ** **
GT 0.97 0.71–1.31 0.83
TT 1.12 0.42–3.00 0.82
≥30 1,501
G894T GG ** ** **
GT 0.86 0.64–1.15 0.30
TT 0.53 0.18–1.58 0.25

NOS3, endothelial nitric oxide synthase 3; n, number; OR, odds ratio; CI, confidence interval; p, p-value adjusted for age, sex, and field center; BMI, body mass index,

1

interaction term for NOS3 G894 TT genotype and obesity;

**

reference genotype.