Table 4. Association of NOS3 genotype and diabetes case status in African Americans stratified by obesity.
Variable | Genotype | BMI | kg/m2 | n | OR | 95% CI | p |
All | 3,737 | ||||||
Obesity(BMI ≥30 kg/m2) | 2.53 | 2.13–3.01 | <0.001 | ||||
Interaction1 | 0.47 | 0.11–2.06 | 0.32 | ||||
G894T | GG | ** | ** | ** | |||
GT | 0.91 | 0.74–1.12 | 0.37 | ||||
TT | 0.79 | 0.38–1.63 | 0.52 | ||||
<30 | 2,236 | ||||||
G894T | GG | ** | ** | ** | |||
GT | 0.97 | 0.71–1.31 | 0.83 | ||||
TT | 1.12 | 0.42–3.00 | 0.82 | ||||
≥30 | 1,501 | ||||||
G894T | GG | ** | ** | ** | |||
GT | 0.86 | 0.64–1.15 | 0.30 | ||||
TT | 0.53 | 0.18–1.58 | 0.25 |
NOS3, endothelial nitric oxide synthase 3; n, number; OR, odds ratio; CI, confidence interval; p, p-value adjusted for age, sex, and field center; BMI, body mass index,
interaction term for NOS3 G894 TT genotype and obesity;
reference genotype.